Matthieu Raoux
Associate Professor, HDR
University of Bordeaux, Institute of Chemistry & Biology of Membranes & Nano-objects, CBMN, UMR 5248 CNRS
http://www.cbmn.u-bordeaux.fr/26-biologie-et-biotechnologie-mecanismes-et-regulation-du-transport-de-vesicules.html#trombinoscope
https://sts.u-bordeaux.fr/actualites/matthieu-raoux-laureat-prix-auguste-loubatieres-2022
“Decoding microorgan function with transdisciplinary tools for biomedical applications”
Better understanding and curing living organs requires the combination of transdisciplinary expertise. The islets of Langerhans in the pancreas are fascinating, vital and complex microorgans, ~100 µm in diameter, which regulate blood glucose, nutrient metabolism and are involved in diabetes, the most common chronic metabolic disease. In this talk, I will present our transdisciplinary works since 2008 between biology, microelectronics, polymer chemistry, electrochemistry, material science, microfluidics, control theory and clinics to develop high resolution sensors with automatic real-time analysis of islet function. Our approaches have already provided major advances in understanding the physiology and pathophysiology of these microorgans and open biomedical applications in the field of diabetes.
REFERENCES
Abarkan et al. (2022) Vertical organic electrochemical transistors and electronics for low amplitude micro-organ signals. Advanced Science. 9:e2105211.
Fischer KL et al. (2021) Pancreatic α and β cells: Best enemies or partners for life? Med Sci. 37(8-9):752-758.
Jaffredo et al. (2021) Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets. Diabetes. 70(4):878-888.
Olcomendy et al. (2022) Integrating an islet-based biosensor in the artificial pancreas: in silico proof-of-concept. IEEE Trans Biomed Eng. 69(2):899-909.
Perrier R et al. (2018) Bioelectronic organ-based sensor for microfluidic real-time analysis of the demand in insulin. Biosens Bioelectron. 117:253-259.a